Apollo Research and Innovations(ARI)
Spearheading Healthcare Research and Innovations for Apollo Hospitals
Apollo Research Initiatives
www.aherf.org
Apollo Research and Innovations
About
us
The Apollo Mission
A promise that redefined Healthcare
Our mission is to bring healthcare of
international standards within the reach
of every individual. We are committed to the
achievement and maintenance of
excellence in education, research and
healthcare for the benefit of humanity
VITAL ELEMENTS
IN OUR VISION FOR
THE FUTURE.
About
us
• An unwavering dedication
to clinical excellence
• A relentless pursuit of expertise
• The ever-tender Apollo empathy
• Strong focus on future-ready healthcare
through education & research
Dr. Prathap C Reddy
Founder Chairman - Apollo Hospitals Group
Apollo Legacy
A snapshot of a revolution
• Touched 40 million lives
• 9.5 million Preventive Health Checks
• Patients from 120 countries
• 140,000 Heart Surgeries
• Over 20000 Joint Replacements
• First Liver Transplant in Children & Adults and performed
over 1200 Liver Transplants
• First Multi-Organ Transplant
• Over 12,000 Kidney Transplants
• Busiest Solid Organ Transplant programme in the world
About
us
About
us
Map is only an indication of our
presence in various cities / towns and
is for reference only.
IMPACTFUL
GROWTH
THAT MAPS
PERFECTLY
TO THE NEEDS
OF THE
COUNTRY
• 20,000 Foot Falls
• 1,500 Admissions
• 800 Major Surgeries
• 600 CT Scans
• 300 MRI
• 40 Cardiac Surgeries
• 350 Dialysis
• 3-4 Organ Transplants
• 1,000 Health Checks
A DAY AT
APOLLO HOSPITALS
THE
APOLLO
CIRCLE
OF LIFE.
Integrated
Model
ARI Vision
Enable a Research & Innovations led Apollo
Hospitals, which consistently rides the cutting
edge in Technology, Therapy, Delivery for
improved patient outcomes, affordability and reach...
Apollo Research and Innovations
Work Scope: Pursuing a vibrantportfolio…
Clinical Research
Clinical Research Training
Basic & Public Health Research
Personalized Medicine
Research & Innovations ventures
Technology Evaluation
Thought leadership
Chennai
Hyderabad
Ahmedabad
Delhi
Bangalore
Mysore
Madurai
Bhubaneswar
Enabling a Research led Apollo Hospitals…
Vizag
Bilaspur
Apollo Research and Innovations
Clinical Trials:
High Focus on Quality Assurance and Patient Safety
800 global multi-centric clinical trials
200 trials across India (any time)
14 years of site management experience
18 operational sites
100% GCP compliance
More than 200 PI’s and 60 CRC’s
Trials across 6 leading therapeutic areas
Access to diverse patient pools
State-of-art Clinical Trial Management System
Potential to take in more than 200
trials at any given time
More than 80 % trials are
multicentric
66% Phase III
14% Phase II
15% Phase IV
5% Other (Device, FMCG,
Software, Observational)
Apollo Research and Innovations
Capability: An ARI Edge
An experienced, centralized & Professional team
SPOC for Clinical
Trial Site Solutions
Clinical Trials
Management
System (CTMS)
18 networked sites
800 clinical studies
with 200 studies on
ground at any point of
time
Resources
DCGI Registered
ECs with a uniform
SOP
60 GCP certified CR
Coordinators
200 GCP certified
PIs on our panel
100 willing
Clinicians
Reach Framework
Drugs, Devices,
Software, FMCG,
others
US FDA visited ARI
sites
Credentials
Over 60 professionals
trained every year
Availability of
Satellite sites
Apollo Research and Innovations
Clinical Research Courses:
Leveraging Experience to Evolve Clinical Research
Education
Advanced Certificate Course in Clinical Research
ARI and Anna University
Pan India course across 5 cities comprising of 16 modules
Clinical research education in a hospital environment
Unique course design: 4 months Theory, 2 months Focused Applied
Learning and 6 months Internship (at ARI Clinical Trial Unit )
Highest Faculty : Student Ratio – Only 20 students per batch
Optimal faculty mix from Academia, Industry and Institutions
95% student placement, at leading CROs, SMOs and Pharmaceutical Companies
Chennai I Hyderabad I Kolkata I Delhi I Ahmedabad
Only course in India comprising
of internship –preparing
students for industry…
Also offer customized training solutions to industry
Apollo Research and Innovations
Basic and Epidemiological
Research
Epidemiological Research
• MoU with INCLEN; Won grant from ICMR on Fatty Liver
disease project
• Multi-centric study on Fatigue completed
• Haematological and biochemical parameters survey
Basic Research
• Genetic association of Coronary Artery Disease in young Indian adults -204
samples collected; Gene expression completed for Phase 1
• Pathogen detection and discovery through high Throughput Platforms with
ICGEB
• Characterization of Endothelial Progenitor Cells in Polycystic Ovary
Syndrome (PCOS) with IIT Madras
• Study to develop a prognostic biomarker for breast cancer; Phase 1
completed; Short-listed 30 gene signatures from 150 –with a leading Pharma
MNC
Apollo Research and Innovations
Research Grants Program:
Seeding clinical research projects across the
Apollo Hospitals Network
Provided research grants to over 21 projects
3 Projects submitted to Department of
Biotechnology, Govt of India
5 more projects in pipeline
Final Submission and
Selection
Review of
the Draft
Funding
of Ideas
Collation
and
Filtering
of Ideas
“A comparative study of enteral vs IV rehydration in dengue illness” ,
Apollo Children’s Hospitals Chennai.
“Prevalence of vitamin D {25(OH)D} deficiency, its association with type 2
diabetes patients.”, Apollo Hospitals, Bilaspur
“Evolution of fronto-temporal lobar degeneration and its relation with
molecular genetics, imaging and neuro-chemical markers”,
A few of our projects
Apollo Research and Innovations
Tissue Banking and
Research
Vision of Apollo-Saarum: India’s largest financially sustainable Biobank
Bio-bank
Apollo-
Saarum
Apollo
Hospitals
Clinic Facing Services , Apollo-Saarum
Patient Facing Services
Treatment Optimization
Molecular Diagnostics
Clinical Support Services
Stratification of clinical trial populations
Research Support & Bio-repository
Services
Drug Discovery & Services, Saarum
Create custom cell lines & tumour
microarrays
Target & Biomarker Services
Discovery & validation using primary human cells
Genomics & proteomics services
Drug Discovery related Services
Idea-to-IND phase collaborative drug discovery
programmes
Human Cell based Phenotype screening
services
Apollo Research and Innovations
Key Achievements: Life Sciences
Incubated Sapien Bio-Sciences (An Apollo company)
MyPlatelet:
Personalized blood thinning
medication post stent/CABG; 200
tests -6 months-hyd & bhubaneshwar
Genetic Risk Assessment:
-For CVD, diabetes & obesity with
nutri-genomics
-preventive healthchecks enable
behavioral change
Clinical Genomics:
For differential diagnosis, better
disease mgmt & family screening -
Eye, cancer & CVD panels
Peri-natal genetics:
Pre-natal testing
New-born screening
Standardized, white labelled &
customized for Apollo
Bio-Bank:
Creating India’s largest bio-repository
Samples & info priceless for drug discovery,
diagnostics
Harvard, Astra Zeneca, DRL interested
Diagnostic Collaborations:
Prostrate cancer diagnostics
Apollo Research and Innovations
Key Developments: Software
Forged Collaboration with Analytics for Life -
Detect a range of cardiac health issues and
abnormalities from a simple non-invasive ECG test
2 tranches of study (64 subjects) completed with
over 85% sensitivity & specificity
3
rd
tranche completed with encouraging results of
Sensitivity & Specificity
Extension Study with 1000 subjects - May 14
Clinician verdict (so far): Tool applicable for mass
screening
A potentially disruptive non-invasive Screening tool for Cardio-vascular Disease
Apollo Research and Innovations
CRO Activities – Ambulatory BP
Management Trial
The Study is an observational study to assess the
correlation of Ambulatory Blood Pressure
Monitoring(ABPM) versus Office Blood Pressure
Monitoring(OBPM) in patients newly diagnosed
with High Blood Pressure
The Study is a 1000 patient study across 13
different ARI sites and 100 investigators
The scope of the work by ARI includes document
preparation, monitoring, recruitment, data
gathering and management, analysis and report
writing
A large multicentric study with a vision of changing the paradigm in hypertension
management
Apollo Research and Innovations
Key Developments: Devices
Forged Collaboration with Medtronic
A potentially disruptive healthcare delivery model in Dialysis
Improve access to care for End Stage Renal
Disease (ESRD) patients
Medtronic creating an advanced
dialysis device with clinical &
operational insights from Apollo
Device will need 6 ltrs of water Vs.
120 ltrs of water/ session
Lower risk to patient
Making mobile dialysis a reality
Apollo Research and Innovations
Key Developments: Biomarkers
Diagnostic for Glioblastomas
Blood based (non-invasive) cancer diagnostic for
Glioblastoma Multiform (GBM)
Pilot data indicates positive results
Larger study to commence shortly
Indian pre-disposition to CVD
Completed pilot study on genetic risk assessment in
Indians predisposing them to cardiovascular disease
used a state-of-art technology platform, to perform
genomic data analysis for detecting genome specific
signatures and associations
DNA sample of each individual was genotyped
Genetic pathway analysis in progress
Apollo Research and Innovations
Key Collaborations
Philips (Medical
Device studies & IP)
Anna University,
Chennai - Education
Nestle (Non Drug Studies)
Parexel – Drug Trials
Drug Trials & Training
Dialysis Device Innovation
Apollo Research and Innovations
Technologies under Evaluation…
and many more…
Early warning hand held
Breast Cancer Screening
ECG for Home Care
Technology for measuring
intra-cranial pressure
Non invasive Prostate
Cancer Screening using
Urine Sample
Skin repair for burns
1
2 3
4 5
Apollo Research and Innovations
Creating an eco-system for Research & Innovations…
Apollo Research and Innovations
“Every great advance in science has issued from a new audacity
of the imagination”
-John Dewey
Apollo Research and Innovations
